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Screening of Selected Medicinal Plants for Their Antifungal Properties

MERCY Itohan ABOH, Peters Oladosu, Gbonbola Adeshina, Busayo Olayinka, Steve Olonitola.

Abstract
Objectives: The rising incidence of fungal infections has created the need for the next generation of antifungal agents, as many of the currently available ones either have adverse effects, or are not active against emerging or re-emerging fungi, leading to the fast progression of resistant strains. This study aims at evaluating the antifungal activities of some medicinal plants used traditionally for treating skin infections in Nigeria. Methods: In vitro antifungal activities of seven indigenous plants (Leptadenia hastate, Lawsonia inermis, Hyptis suaveolens, Luffa cylindrica, Jatropha curcas, Pterocarpus erinaceus and Afromaxia laxiflora) were screened against Candida albicans ATCC 10231, Candida tropicalis ATCC 13803, clinical strains of Candida albicans, Candida tropicalis, Trichophyton rubrum, Microsporum canis and Epidermophyton floccosum using agar dilution and microbroth dilution methods. Terbinafine and fluconazole were used as reference standards in order to compare. Results: The results showed that the ethanol and ethyl acetate extracts of the plants produced better antifungal effects than the hexane and water extracts. L. cylindrica and H. suaveolens exhibited the strongest inhibitory activity against all the fungi tested with minimum inhibitory concentration values ranging between 250 and 1000 µg/mL. Conclusion: The plants screened could serve as leads for the development of new antifungal drugs.

Key words: Antifungal, agar dilution, micro broth dilution, minimum inhibitory concentration.



Seçilmiş Tıbbi Bitkilerin Antifungal Özelliklerinin İncelenmesi

Özet
Amaç: Mantar enfeksiyonlarının insidansındaki artış, kullanımda olanların yan etkileri veya görülen-yeniden alevlenen enfestasyonlara karşı etkinlikleri ve dirençli suşların hızlı yayılımı nedenleri ile yeni nesil antifungal ajanların geliştirilmesine ihtiyaç vardır. Bu çalışma Nijerya’da dermal mantar enfeksiyonlarının tedavisinde geleneksel olarak kullanılan bitkisel ilaçların antifungal etkinliklerini değerlendirmeyi amaçlandı.
Yöntem: Yedi yöresel bitkinin (Leptadenia hastate, Lawsonia inermis, Hyptis suaveolens, Luffa cylindrica, Jatropha curcas, Pterocarpus erinaceus and Afromaxia laxiflora) Candida albicans ATCC 10231, Candida tropicalis ATCC 13803, clinical strains of Candida albicans, Candida tropicalis, Trichophyton rubrum, Microsporum canis and Epidermophyton floccosum üzerindeki etkinliği agar dilüsyon ve mikrobrot dilüsyon metodları ile indelendi.
Bulgular: Bitkilerin etanol ve etil asetat ekstraktlarının hekzan ve su ekstraktlarından daha iyi antifungal etkinlik gösterdiği görüldü. L. cylindrica ve H. suaveolens 250 and 1000 µg/mL. minimum inhibisyon konsantrasyon değerlerinde, bütün mantar tipleri için en yüksek inhibisyon etki düzeylerine sahipti.
Sonuç: Bitkiler yeni antifungal ilaçlar geliştirmek amacıyla incelenebilir.

Anahtar Kelimeler: Agar dilüsyon, mikrobrot dilüsyon, minimum inhibitor konsantrasyon.


 
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How to Cite this Article
Pubmed Style

ABOH MI, Oladosu P, Adeshina G, Olayinka B, Olonitola S. Screening of Selected Medicinal Plants for Their Antifungal Properties.



Web Style

ABOH MI, Oladosu P, Adeshina G, Olayinka B, Olonitola S. Screening of Selected Medicinal Plants for Their Antifungal Properties. www.scopemed.org/?mno=223518 [Access: November 24, 2017].



AMA (American Medical Association) Style

ABOH MI, Oladosu P, Adeshina G, Olayinka B, Olonitola S. Screening of Selected Medicinal Plants for Their Antifungal Properties.



Vancouver/ICMJE Style

ABOH MI, Oladosu P, Adeshina G, Olayinka B, Olonitola S. Screening of Selected Medicinal Plants for Their Antifungal Properties.



Harvard Style

ABOH, M. I., Oladosu, P., Adeshina, G., Olayinka, B. & Olonitola, S. (0) Screening of Selected Medicinal Plants for Their Antifungal Properties.



Turabian Style

ABOH, MERCY Itohan, Peters Oladosu, Gbonbola Adeshina, Busayo Olayinka, and Steve Olonitola. 0. Screening of Selected Medicinal Plants for Their Antifungal Properties.



Chicago Style

ABOH, MERCY Itohan, Peters Oladosu, Gbonbola Adeshina, Busayo Olayinka, and Steve Olonitola. "Screening of Selected Medicinal Plants for Their Antifungal Properties."



MLA (The Modern Language Association) Style

ABOH, MERCY Itohan, Peters Oladosu, Gbonbola Adeshina, Busayo Olayinka, and Steve Olonitola. "Screening of Selected Medicinal Plants for Their Antifungal Properties."



APA (American Psychological Association) Style

ABOH, M. I., Oladosu, P., Adeshina, G., Olayinka, B. & Olonitola, S. (0) Screening of Selected Medicinal Plants for Their Antifungal Properties.



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