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Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents

Emmanuel Olorunju Awe, Modupe Janet Makinde, Kamoru Olayemi Wakeel1, Simeon Olatunde Kolawole.

Abstract
AIM: The continued search for potential and safe anti-inflammatory agents is important, in view of the roles played by proinflammatory factors in diseases such as asthma, rheumatoid arthritis, cancer and neurodegerative disorders. The Nigerian flora is rich in medicinal plants which are employed in traditional folk medicine for various inflammatory disorders. We therefore evaluate the antiinflammatory activity of the aqueous extract of the leaves of.
METHOD: The antiinflammatory activity was evaluated using egg albumin, agar-induced paw edema models for acute inflammation, complete Freud Adjuvant (CFA)-induced arthritis and cotton pellets granuloma models for chronic inflammation in rats.
RESULTS: PSE, produced significant (P

Key words: Pyrenacanthia Staudtii, Aqueous Extract, Anti-İnflammatory Activity



Kemirgenlerde Pyrenacanthia Staudtii Engl. (Icacinaceae) Bitkisinin Sıvı Yaprak Ekstresinin Antiinflamatuar Etkisi

Özet
GİRİŞ: Astım, romatoid artrit, kanser ve nörodejeneratif bozukluklar gibi hastalıklarda, proinflamatuar faktörlerin rolleri açısından, potansiyel ve güvenli anti-inflamatuar ajanlar için yapılan sürekli aramalar önemlidir. Nijerya’nın florası tıbbi bitkiler bakımından zengin olup, bu bitkiler geleneksel halk tıbbında çeşitli enflamatuar hastalıklar için kullanılmaktadır. Bu kapsamda Pyrenacanthia staudtii Engl. (Icacinaceae) (PSE) yapraklarının sulu ekstresinin antienflamatuar aktivitesi incelenmiştir.
METOD: Antiinflamatuvar aktivite; yumurta albumin, agar-akut inflamasyon için modeli, komple Freud Adjuvanı (CFA)-indüklenmiş artrit ve sıçanlarda kronik inflamasyon için pamuk pellet granülom modelleri kullanılarak değerlendirilmiştir.
BULGULAR: PSE, pençe ödemi miktarını doz bağımlı olarak azaltmıştır (100-400 mg/kg) ve bu azalış istatistiksel olarak anlamlıdır (P

Anahtar Kelimeler: Pyrenacanthia Staudtii, Sulu Ekstrakt, Anti-İnflamatuar Etkinlik


 
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How to Cite this Article
Pubmed Style

Awe EO, Makinde MJ, Wakeel KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. 2010; 9(4): 297-302.



Web Style

Awe EO, Makinde MJ, Wakeel KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. www.scopemed.org/?mno=1338 [Access: September 19, 2017].



AMA (American Medical Association) Style

Awe EO, Makinde MJ, Wakeel KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. 2010; 9(4): 297-302.



Vancouver/ICMJE Style

Awe EO, Makinde MJ, Wakeel KO, Kolawole SO. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull. (2010), [cited September 19, 2017]; 9(4): 297-302.



Harvard Style

Awe, E. O., Makinde, M. J., Wakeel, K. O. & Kolawole, S. O. (2010) Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Prev Med Bull, 9 (4), 297-302.



Turabian Style

Awe, Emmanuel Olorunju, Modupe Janet Makinde, Kamoru Olayemi Wakeel, and Simeon Olatunde Kolawole. 2010. Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Preventive Medicine Bulletin, 9 (4), 297-302.



Chicago Style

Awe, Emmanuel Olorunju, Modupe Janet Makinde, Kamoru Olayemi Wakeel, and Simeon Olatunde Kolawole. "Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents." TAF Preventive Medicine Bulletin 9 (2010), 297-302.



MLA (The Modern Language Association) Style

Awe, Emmanuel Olorunju, Modupe Janet Makinde, Kamoru Olayemi Wakeel, and Simeon Olatunde Kolawole. "Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents." TAF Preventive Medicine Bulletin 9.4 (2010), 297-302. Print.



APA (American Psychological Association) Style

Awe, E. O., Makinde, M. J., Wakeel, K. O. & Kolawole, S. O. (2010) Antiinfammatory Effects of Pyrenacanthia Staudtii Engl. (Icacinaceae) Aqueous Leaf Extract in Rodents. TAF Preventive Medicine Bulletin, 9 (4), 297-302.



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The articles in TAF Preventive Medicine Bulletin are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.